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Image Search Results
Journal: bioRxiv
Article Title: Arsenite methyltransferase 3 regulates hepatic energy metabolism which dictates the hepatic response to arsenic exposure
doi: 10.1101/2023.04.05.535637
Figure Lengend Snippet: A . Representative images of WT and as3mt -/- larvae and adults. B-C . Standard length of larvae (μM; B) and adults (cm; C). D . Average IC-ICP-MS counts of AsB, AsIII, DMA, and MMA from WT (grey) or as3mt -/- (pink) zebrafish extracts after 0 (dotted lines) or 1 mM iAs (6-120 hpf) challenge (solid lines) (n = 40, 2 clutches). E . Percent survival of WT (grey) and as3mt -/- (pink) across 0, 0.5, 1.0, 1.5 and 2.0 mM iAs exposure from 6-120 hpf. Intersect with green line denotes the LC 50 . n = ∼60, 3 clutches. F . Representative images of WT and as3mt -/- larvae during 0 mM, 1 mM acute (96-120 hpf), or 1 mM chronic (6-120 hpf) exposure to iAs. G . Images of 120 hpf zebrafish pigmentation at 0 mM or 1 mM chronic (6-120 hpf) iAs challenge (purple). Orange arrows mark pigmentation clusters. H . Quantification of pigmentation per larvae (n = 5-10, 1 clutch). I . Percent phenotype (normal (white), abnormal (grey) or dead (black) after 0-2 mM iAs exposure from 6-120 hpf (n = ∼60, 3 clutches).
Article Snippet: IC-ICP-MS standards were: As(III) (Arsenic (III) Standard, Fisher Scientific; 1327-53-3), As(V) (Arsenic V Speciation Standard, Fisher Scientfic; 7732-18-5, AsB (Arsenobetaine Standard Solution, LGC Standards; NIST-3033), DMA (Dimethylarsinic Acid Standard Solution, LGC Standards; NIST-3031) and
Techniques: